Welcome to the "Great White Wasteland," a desolate expanse covering Canada in the year 2293, over two centuries after a devastating war. This post-apocalyptic setting is fraught with mutants, raiders, and remnants of a shattered society.
In the east, the Brotherhood of Steel strives to impose order, while the west sees NCR squads and Legionnaires expanding their reach. Super mutants are common on the west coast, accepted by locals, but ghouls on the east coast face distrust and exclusion.